January 2025

Buffer Calculation Fundamentals Phosphate Buffer Example For the system containing sodium phosphate monobasic(NaH2PO4), sodium phosphate dibasic(Na2HPO4), and sodium chloride (NaCl), weapply first principles methods to calculate pH, involvingdissociation equilibrium, and charge balance. Dissociation Equations and Equilibrium Constants for PhosphoricAcid: Phosphoric acid (H3PO4) is a triprotic acid,meaning it can donate three protons (H+), each step withits […]

  User Guide Introduction Welcome to Expert Buffer Designer, a comprehensive tool that enables you to design your buffers. The calculation engine is a first-principles-based predictor and has been time-tested. The algorithm used is so powerful, robust, and fast that it can handle the very non-linear nature of the solution. The Henderson-Hasselbalch equation is typically

Step 1: Pick Acidic and Basic Compounds Pick the one that contains the buffering species you want from the first drop-down list, which lists acidic compounds. Alternatively, you can pick a non-buffering compound from this list. However, you have to make sure you pick a buffering compound from the basic compound list below. From the

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